解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:INTRODUCTION:The FloTrac/Vigileo (Edwards Lifesciences, Irvine, CA, USA) allows pulse pressure-derived cardiac output measurement without external calibration. Software modifications were performed in order to eliminate initially observed deficits. The aim of this study was to assess changes in cardiac output determine...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7739
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS:Male NMRI mice were subjected to femur fracture/hemorrhagic shock and ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7963
更新日期:2009-01-01 00:00:00
abstract::The early recognition and management of sepsis remain the greatest challenges in the field of critical care medicine. Endothelial injury is one of the hallmarks of sepsis, leading to capillary leak, microcirculatory dysfunction, organ failure, and eventual death in many critically ill patients. The angiogenic growth f...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章,评审
doi:10.1186/cc7685
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The effect of sepsis on epidermal wound healing has not been previously studied. It was hypothesised that epidermal wound healing is disturbed in severe sepsis. METHODS:Blister wounds were induced in 35 patients with severe sepsis and in 15 healthy controls. The healing of the wounds was followed up by me...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7932
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Appropriate care for patients with tracheostomies in hospital settings is an important issue. Each year more than 7000 patients receive tracheostomies in Australia and New Zealand alone. Many of these tracheostomy patients commence their care in the intensive care unit (ICU) and once stabilised are then tr...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc8159
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Bacterial meningitis (BM) is a severe complication in patients with aneurysmal subarachnoid haemorrhage (SAH). Clinical signs of meningitis are often masked by SAH-related symptoms, and routine cerebrospinal fluid (CSF) analysis fails to indicate BM. Microdialysis (MD) is a technique for monitoring cerebra...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7689
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Serum B-type natriuretic peptide (BNP) is frequently elevated after subarachnoid hemorrhage (SAH), but whether this high BNP level is related to transient elevation of left ventricular filling pressure (LVFP) is unknown. However, in patients with preexistent cardiac pathologies, it is impossible to differe...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7891
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Unawareness of an asymmetry between the right and left internal jugular vein (IJV) and methodological pitfalls in previous studies raise concerns about such asymmetry. Hence the aim of this prospective non-interventional study was to validate the hypothesis that right IJV diameter is greater than those of ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8200
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc8202
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Delayed gastric emptying occurs frequently in critically ill patients and has the potential to adversely affect both the rate, and extent, of nutrient absorption. However, there is limited information about nutrient absorption in the critically ill, and the relationship between gastric emptying (GE) and ab...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8021
更新日期:2009-01-01 00:00:00
abstract::Great variability exists in data collection and coding of variables in studies on traumatic brain injury (TBI). This confounds comparison of results and analysis of data across studies. The difficulties in performing a meta-analysis of individual patient data were recently illustrated in the IMPACT project (Internatio...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8163
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The anaesthetic agent propofol (2,6-diisopropylphenol) has been shown to be an effective neuroprotective agent in different in vitro models of brain injury induced by oxygen and glucose deprivation. We examined its neuroprotective properties in an in vitro model of traumatic brain injury. METHODS:In this ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7795
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc8197
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:To determine whether subjecting patients to 100 ml of additional dead space after a 120-minute weaning trial could predict readiness for extubation. METHODS:This was a prospective, non-randomised pilot study in an intensive care unit at a university hospital with 14 beds. It included all non-tracheostomis...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc7783
更新日期:2009-01-01 00:00:00
abstract::High mobility group box protein 1 (HMGB1) has been shown to participate in acute inflammatory reactions, including acute lung injury and sepsis. There is also evidence that circulating levels of HMGB1 are increased after severe trauma and are associated with clinically important outcome parameters, including mortality...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc8141
更新日期:2009-01-01 00:00:00
abstract::In a group of postoperative patients, Taniguchi and coworkers compared the effect of a computerized system for weaning against 'manual care'. The computerized system involved automatic adjustments to the level of pressure support to achieve a target respiratory rate. Manual care involved adjustments to the level of pr...
journal_title:Critical care (London, England)
pub_type: 评论,杂志文章
doi:10.1186/cc7746
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Survival after cadaveric lung transplantation (LTx) in respiratory failure recipients who were already dependent on ventilation support prior to transplantation is poor, with a relatively high rate of surgical mortality and morbidity. In this study, we sought to describe the short-term outcomes of bilatera...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7989
更新日期:2009-01-01 00:00:00
abstract::Hydrogen sulfide (H2S), a gas with the characteristic odor of rotten eggs, is known for its toxicity and as an environmental hazard, inhibition of mitochondrial respiration resulting from blockade of cytochrome c oxidase being the main toxic mechanism. Recently, however, H2S has been recognized as a signaling molecule...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7700
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Norepinephrine, regularly used to increase systemic arterial blood pressure and thus improve cerebral perfusion following severe traumatic brain injury (TBI), may activate platelets. This, in turn, could promote microthrombosis formation and induce additional brain damage. METHODS:The objective of this st...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6931
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Many patients experience 'relocation stress' when they are transferred from an intensive care unit (ICU) to step-down (high dependency) or general ward care, and much has been written about the psychological causes. This qualitative analysis of in-depth, narrative interviews with former ICU patients explor...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6795
更新日期:2008-01-01 00:00:00
abstract::The Surviving Sepsis Campaign guidelines for the management of severe sepsis and septic shock recommend that the initial hemodynamic resuscitation be done according to the protocol used by Rivers and colleagues in their well-known early goal-directed therapy (EGDT) study. However, it may well be that their patients we...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6979
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Patients after out-of-hospital cardiac arrest (OHCA) benefit from therapeutic hypothermia for 24 hours. The time needed to reach hypothermia (target temperature of 32 degrees C to 34 degrees C) varies widely. In this study, we explore the relation between measures of body composition and the time needed to...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6954
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:During septic shock, resistance to the haemodynamic effects of catecholamine vasopressors and inotropes is a well-recognised marker of mortality risk. However, the specific cardiovascular or metabolic response elements that are most closely associated with outcome have not been well defined. The objective ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6814
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan (HMW HA), in contrast, has been found to be anti-inflammatory. We hypothesi...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6982
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:This study pools data from the UK Intensive Care National Audit and Research Center (ICNARC) Case Mix Programme (CMP) to evaluate the case mix, outcome and activity for 17,326 patients with severe acute kidney injury (AKI) occurring during the first 24 hours of admission to intensive care units (ICU). MET...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7003
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and is known to be a severe disease with a high mortality rate. The treatment of MALA with dialysis is controversial and is the subject of many case reports in the literature. We aimed to assess the prevalence of MALA in a 16...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7137
更新日期:2008-01-01 00:00:00
abstract::The impressive benefits related to the use of tight glucose control by intensive insulin therapy have not been reproduced until now in multicenter large-scale prospective randomized trials. Although the reasons for these failures are not entirely clear, we suggest the use of a stepwise approach - Safe, Effective Gluco...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc6889
更新日期:2008-01-01 00:00:00
abstract::The US Institute of Medicine's focus on patient safety has motivated hospital administrators to facilitate a culture of safety. As a result, subcommittees of the pharmacy and therapeutics committee have emerged in many hospitals to focus on adverse events and patient safety. Antimicrobial harms have gained the attenti...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc6819
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The ai...
journal_title:Critical care (London, England)
pub_type: 杂志文章,随机对照试验
doi:10.1186/cc6887
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:The goal of personalised medicine in the intensive care unit (ICU) is to predict which diagnostic tests, monitoring interventions and treatments translate to improved outcomes given the variation between patients. Unfortunately, processes such as gene transcription and drug metabolism are dynamic in the cr...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7140
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Curricular content is often based on the personal opinions of a small number of individuals. Although convenient, such curricula may not meet the needs of the target learner, the program or the institution. Using an objective method to ensure content validity of a curriculum can alleviate this issue. METH...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7087
更新日期:2008-01-01 00:00:00
abstract::There has been a lot of debate about the concept of relative adrenocortical insufficiency (often defined as a reduced response to corticotropin) as a pathophysiological explanation of steroid effects in septic shock. Less is known about the prevalence of absolute adrenocortical insufficiency based on more usual defini...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6926
更新日期:2008-01-01 00:00:00
abstract::Bacterial pathogens possess an array of specific mechanisms that confer virulence and the capacity to avoid host defence mechanisms. Mechanisms of virulence are often mediated by the subversion of normal aspects of host biology. In this way the pathogen modifies host function so as to promote the pathogen's survival o...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7091
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Our understanding of septic acute kidney injury (AKI) remains incomplete. A fundamental step is the use of animal models designed to meet the criteria of human sepsis. Therefore, we dynamically assessed renal haemodynamic, microvascular and metabolic responses to, and ultrastructural sequelae of, sepsis in...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7164
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Delivery of bronchodilators with a metered-dose inhaler (MDI) and a spacer device in mechanically ventilated patients has become a widespread practice. However, except for the short-acting beta2-agonist salbutamol, the duration of action of other bronchodilators, including long-acting beta2-agonists, deliv...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc7117
更新日期:2008-01-01 00:00:00
abstract::Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform. It is important to interpret the results of such studies in view of our limited ability to diagnose and quantify brain dysfunction and to consider our limited understanding of th...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6217
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Stimulation of beta2-adrenergic receptors (beta2-ARs) inhibits tumor necrosis factor-alpha (TNF-alpha) release in monocytes. In septic shock, endogenous catecholamines induce beta2-AR downregulation, leading to an increased TNF-alpha release. The aims of this study were to analyze the molecular mechanisms ...
journal_title:Critical care (London, England)
pub_type: 杂志文章
doi:10.1186/cc7158
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). METHODS:Medline, EMBASE and other databases were searched for English-language articles with the major objective of ...
journal_title:Critical care (London, England)
pub_type: 杂志文章,评审
doi:10.1186/cc7160
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:In severely neutropenic septic acute respiratory distress syndrome (ARDS) patients, macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown, however, a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study, we tr...
journal_title:Critical care (London, England)
pub_type: 临床试验,杂志文章
doi:10.1186/cc6791
更新日期:2008-01-01 00:00:00
abstract::Sepsis is one of the most common conditions encountered in the intensive care unit and is the 10th leading cause of death overall in the United States. Both long-term survival and health-related quality of life are reduced in survivors of sepsis, yet there is little knowledge of the effect of sepsis-specific intervent...
journal_title:Critical care (London, England)
pub_type: 评论,社论
doi:10.1186/cc6215
更新日期:2008-01-01 00:00:00